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LSD test was used for pairwise comparison of means between multiple groups when variance was homogeneous, and Mann-Whitney U test was used for comparison when variance was heterogeneous

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RSL3 contains a reactive chloroacetamide moiety that makes it a potent and irreversible GPX4 inhibitor, although its poor solubility and poor absorption, distribution, metabolism, and excretion (ADME) properties limit its effectiveness in in-vivo studies [22]