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Cancers (Basel) 12(2):310 Okazaki A, Gameiro PA, Christodoulou D (2017) Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers

Dysfunctional mitochondria can undergo permeabilization and fragmentation, leading to the release of mitochondrial components such as mtDNA into the cytoplasm and extracellular space [134]

This results in a sudden spike in BAC

Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2

Continued research into understanding these crossroads is critical for designing combination treatments (that target two or more death modalities) to improve therapeutic outcomes