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For use, aspirin and L-MS were dissolved in dimethyl sulfoxide (DMSO, #13445-74, Nacalai Tesque, Kyoto, Japan) to prepare stock solutions of 1 M and 250 mM These were further diluted in the culture medium for experimental use, ensuring a final DMSO concentration of 0.2% across all treatment and control groups

The photolysis of cobalamins depends upon a number of factors, such as the nature of both axial ligands, the local environment, and the excitation wavelengths applied

In most of the participating centres, information on consumption of ASBs was collected (Navarrete-Muoz et al., 2016

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Oral Controlled Studies A randomised four-week study involving 60 healthy participants reported statistically greater reductions in melanin index at two of six measured sites