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Moreover, the abundance of GSH (110 mmol L 1 ) might favour the spontaneous reaction between GSH and FA, which, if not limited, could alter the GSH:GSSG ratio leading to oxidative stress

This crosstalk may reduce TLR4 signaling when the ER is activated

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For instance, transcription factors can exert other immediate actions: STAT3 has been shown to limit infarct size shortly after activation by directly influencing mitochondrial function in mice, rats, and pigs