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Moreover, GLPs suppress NOX4 expression, decrease H 2 O 2 and MDA accumulation, and boost the enzymatic activity of key antioxidantsincluding SOD, CAT, and GSH-Pxthereby mitigating oxidative stress and associated DNA damage

Acknowledgements The authors would like to thank the technical and supporting team at the study sites (university hospitals) in Berlin, Torino and Chicago