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doi: 10.1038/nrmicro3344 55 ReichardtNDuncanSHYoungPBelenguerAMcWilliam LeitchCScottKPet al

Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase-1

These results together indicate that the ROS induction in response to R001 treatment inhibits the proliferation of TNBC cells and could be blocked by the addition of exogenous anti-oxidant agents