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62 AP-1 and MAPK synergistically upregulate the transcription of matrix metalloproteinases, 63,64 which degrade the follicular basement membrane (eg collagen type IV) and extracellular matrix (ECM), weakening the mechanical stability of the hair follicle and leading to follicular rupture

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Depending on the active site structure, Grx isoenzymes can be dithiol or monothiol (active site sequences Cys-X-X-Cys and Cys-X-X-Ser, respectively) [147]