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Free Radic Biol Med 34:92836, PMID: 12654482 Palamara AT, Perno CF, Ciriolo MR, Dini L, Balestra E, DAgostini C, Di Francesco P, Favalli C, Rotilio G, Garaci E (1995) Evidence for antiviral activity of glutathione: in vitro inhibition of herpes simplex virus type 1 replication

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Thus, weak detoxification of the RAN/tobacco metabolites by GSTP1 Ile/Ile leads to higher induction of oxidative damages to DNA leading to mutagenesis and genomic instability