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According to published studies, cell therapy still faces significant challenges in terms oflong-term safety, treatment durability, cell preparation and cost, individual variability, and delivery methods [149]

Anemia: Overview and Types (e.g., sickle cell disease Sickle cell disease Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (HbS) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage

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We conclude that the DLBCL TME is a source of IL-6 associated with local CAR T cell activation, but IL-6 is predominantly produced by non-CAR cells