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Ferroptosis: a flexible constellation of related biochemical mechanisms

For example, under normal conditions, Keap1 homodimers bind to the ETGE and DLG motifs in the Neh2 region of Nrf2

As a result, the transcription of the COL3A1 and COL1A1 genes, which produce type III and I collagen precursors, is reduced, ultimately leading to a decrease in the amount of type III and I collagen present in the skin (44)

doi: 10.1016/j.jare.2022.07.008, 36