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4a) G6PD is commonly overexpressed in many myeloid and lymphoid malignancies leading to improved proliferation, but this effect can be abrogated by pharmacologic inhibition of G6PD 87

In broad terms, this finding suggests that dysregulation of metabolic pathways, as occurs in obesity, is likely to affect how well the ER can withstand challenges

These modifications are often reversible and can control the expression, activity, and stability of the NRF2 gene, as well as its interactions with other regulatory elements within the cell

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Drug therapy and stem cell therapy have been explored in the treatment of HIE, exhibiting certain neuroprotective effects