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Clinical trials (NCT01967810, NCT01480583, NCT02048059, and NCT01497665), such as those investigating ANG1005 and GRN1005, have explored LRP1-targeting therapeutics, where paclitaxel molecules are covalently linked to Angiopep-2 to enhance BBB penetration and tumor uptake while circumventing P-gp-mediated drug efflux (Table 7) [169,170]

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[DOI] [PubMed] [Google Scholar] 80.Li Y., Jiang W., Feng Y., Wu L., Jia Y., Zhao R