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There is a point of view that understanding mechanisms is not as important as exploring the functional aspects of a phenomenon: we can remain agnostic about mechanism while we investigate and describe function, on the understanding that we will fill in the gaps in our understanding at some later point

2005 Jul

Increased nuclear REST resulted directly decreasing the levels of miR-132 and miR-124a and indirectly via inhibition of BDNF expression consequently leading to inhibition of neurite outgrowth [69]

Any intervention that addresses these fundamental challenges holds promise for improving outcomes

Tesfaw G, Siraj DS, Abdissa A, Jakobsen RR, Johansen H, Zangenberg M, et al