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By engineering a patients T-cells to specifically recognize senescence-associated surface antigens, CAR-T therapy achieves highly precise targeting of SnCs

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FIGURE 3 8.7 The role of ferroptosis in atherosclerosis with depression Ferroptosis influences the onset of AS and depression through inflammation, mitochondrial dysfunction, and gut microbiota, respectively

In addition, as PAH mediates the conversion of phenylalanine (Phe) to tyrosine (Tyr), hyperphenylalaninemia (HPA) is present in all BH 4 deficiencies apart from autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (AD-GTPCHD) and sepiapterin reductase deficiency (SRD) [1, 2]