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Nature 520 , 5762 (2015) Friedmann Angeli, J

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

These modifications can alter enzyme activity, stability, and subcellular localization

Combined with Keap1 for negative regulation Under non-stress conditions, the protein levels of NRF2 are generally maintained at lower levels, which is attributed to the formation of a complex between NRF2 and its negative regulatory protein Keap1 in the cytoplasm