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Cytotoxicity of sorafenib on HCC cells could be alleviated by inhibitors against mitochondrial respiratory chain

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In clinical studies, Glutamine supplementation has been associated with: Reduced abdominal pain Improved stool consistency and frequency Lower overall IBS severity scores Improved gut permeability markers Some research also suggests better results when Glutamine is paired with dietary strategies like a low-FODMAP approach

Furthermore, this study provides evidence for the crosstalk between this pathway and the hypoxic and demonstrates that the specific regulation of BCL9 by HIF-1 may be a potential crosstalk mechanism between the two