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Pyridoxal phosphate (PLP) is integral to one-carbon metabolism, a series of biochemical reactions necessary for the synthesis of nucleotides and other molecules essential for DNA and RNA production (57, 58)

Alterations in glycolysis, glutaminolysis, or serine/glycine metabolism in cancer cells promote survival as a result of increased levels of GSH, which allow tumor cells to withstand their enhanced oxidative environment ( 5 , 9 11 ), and the pentose phosphate pathway, an offshoot of glycolysis, provides NADPH [reduced form of nicotinamide adenine dinucleotide phosphate (NADP + )]reducing equivalents to maintain GSH homeostasis ( 12 )

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FDAs notice frames the question procedurally: these are bulk drug substances nominated for possible inclusion on the 503A Bulks List, and PCAC is being asked to discuss them

My neck was stiff, sore, and I often felt numbness in my shoulders