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When this peroxynitrite reaches the RGCs, it can cause apoptosis if superoxide radicals (O 2 - ) have been generated by reperfusion injury.[59] Additional evidence that peroxynitrite can cause oxidative injury comes from research in monkeys with experimental glaucoma.[60] This sequence of events promotes repeated episodes of vascular dysregulation, causing degeneration of the lamina cribrosa and repetitive unstable BF in the ONH, finally causing RGC death.[61] This mechanism would explain the hypothesized relationship between systemic mitochondrial dysfunction and MD, an indicator of visual loss, in this study

Funding This work was in part supported by Fondi di Ateneo from the Universit della Calabria (to CI, MS, MG, and LP) and in part by PON (Programma Operativo Nazionale) Project No

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29 , 799810.e4 (2022)

The mycotoxins found would dictate the type of treatment or binders being used for treatment