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Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities

A possible role of plasma glutathione in glucose-mediated insulin secretion: in vitro and in vivo studies in rats

These results indicated that the process of oxidative decarboxylation of pyruvate to acetyl-coA is complex, and the key genes regulating PDH need to be further identified

Altered protein binding can affect drug responses because only the "free", unbound drug is active and for a highly protein-bound drug small changes in the extent of protein binding can substantially influence the free drug concentration [free drug]

Overall signal: Reviews summarize broad preclinical benefits but emphasize minimal human data and the need for trials before clinical adoption