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Description

Treatment of mouse mononuclear macrophages with copper sulfate increases mitochondrial reactive oxygen species, activates the Akt/mTOR signaling pathway to promote autophagosome formation, and upregulates the expression of cleaved caspase3/8/9 polymerase, leading to cell apoptosis (135)

J neuro-oncol (2022) 156(1):110

Sensory neurons can release pro-inflammatory neuropeptides such as substance P (SP) and CGRP, which lead to vasodilatation, increased permeability, inflammatory cell extravasation, tissue edema, and other inflammatory manifestations (117)

Yennurajalingam S, Frisbee-Hume S, Delgado-Guay MO, Bull J, Phan AT, Tannir NM , Litton JK, Palmer JL, Reddy AS, Hui D, Dalal S, Massie L, Vadhan-Raj S, Reddy SK, Reuben JM, Bruera E