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doi: 10.3390/ijms26020552

Moreover, DIG exhibited higher positive signal intensity compared to sICIs in the following preferred terms: myocarditis [ROR 2.221, 95% confidence interval lower limit of information component (IC 025 ) 0.486], immune-mediated myocarditis (ROR 2.922, IC 025 0.610), adrenal insufficiency (ROR 2.503, IC 025 0.602), hyperthyroidism (ROR 1.872, IC 025 0.305), thyroiditis (ROR 2.669, IC 025 0.546), immune-mediated enterocolitis (ROR 3.948, IC 025 0.937), pyrexia (ROR 1.570, IC 025 0.290), hepatic function abnormality (ROR 2.582, IC 025 0.591), hepatitis (ROR 2.705, IC 025 0.637), liver disorder (ROR 2.718, IC 025 0.646), immune-mediated hepatitis (ROR 5.504, IC 025 0.994), immune-mediated liver disorder (ROR 5.322, IC 025 0.966), cytokine release syndrome (ROR 7.650, IC 025 1.103), autoimmune diseases (ROR 1.754, IC 025 0.275), sepsis (ROR 1.414, IC 025 0.062), diabetic ketoacidosis (ROR 2.294, IC 025 0.472), type 1 diabetes mellitus (ROR 2.421, IC 025 0.508), arthritis (ROR 1.562, IC 025 0.113), myositis (ROR 2.204, IC 025 0.412), and acute kidney injury (ROR 1.708, IC 025 0.264)

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This increase in leptin is generally a result of the larger adipose tissue mass commonly found in individuals with metabolic dysfunction