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Further investigations are warranted to decipher the early alterations in liver homeostasis upon tumor growth and before the onset of the cachectic phenotype to both identify novel biomarkers to predict cachexia and to find novel insights into the mechanisms triggering the cachectic phenotype

Most protocols start at 2.5 mg per week and increase by 2.5 mg increments every four weeks based on tolerability and response

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Medicine 102 , E33907 (2023)

To uncover the underlying mechanisms, the researchers analyzed hippocampal tissue focusing on dentate gyrus, where they quantified neural progenitor proliferation and neurogenesis through BrdU, immunofluorescence for Sox2, GFAP, DCX and NeuN, and unbiased stereological cell counting