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However, this coupling between the circadian clock and inflammation has been suggested to be reciprocal, with also the circadian clock subjected to inflammation-driven reprogramming

Ferreira N, Goncalves NP, Saraiva MJ, Almeida MR

According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant

These are not reasons to avoid beneficial therapies but rather context for understanding biological complexity

IMCJ: What led you to doing that study and how will you utilize the results