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doi:10.1101/gad.212282.112 Tobaben S, Grohm J, Seiler A et al (2011) Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

In the REPAIR-PD trial (NCT03815916) for PD, completed in 2020, CNM-Au8 demonstrated improvements in brain energy metabolism without significant adverse effects

Unlike the brain and other high-oxygen tissues where ROS generation is largely linked to mitochondrial oxidative phosphorylation, the guts redox balance is shaped by a more complex interplay between host mitochondrial metabolism, microbial ROS/antioxidant production, and immune cell activity

FIGURE 2 3 Relationship between the PFC-Hip-Amycircuit and nueropsychiatric disorders Non-invasive imaging has shown that the PFC, hippocampus and amygdala are interconnected and act in a coordinated manner through direct and indirect neural activity (Nawa and Ando, 2019)