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From the present review, it is evident that small peptides exert towards oral cells and tissues an antitumor activity through apoptosis or selective necrosis of cell lines specifically associated with oral squamous cell carcinoma, an antimicrobial function by maintaining the balance of the oral microbiome, an immunomodulatory function through up and down-regulation of important genes involved in immunoregulatory gene cascades, and finally a cell differentiation function towards major stem cells in the oral cavity, even in absence of growth factors [21, 27,28,29,30,31, 34, 35]

32,33 Nevertheless, its duration of action is rather ephemeral, lasting a mere 12 min within the circulatory system under typical physiological conditions

One study found that when combined with Eucommia, a Chinese herb, chlorogenic acid found in green coffee bean promoted the release of serotonin in rats (x)

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