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3.4 Effect of glutathione administration on 3-MST , CSE and UCP3 expression in heart The determining of the levels of mRNA expression of UCP3 in the heart of adult and old rats did show a significant decrease in expression of UCP3 in old rat hearts compared to the adult, p = .034 (Figure 3A)

However, the lack of targeting of PLGA NPs and the wide variation in brain uptake efficiency by different routes of administration limit the therapeutic efficacy of loaded drugs

Some researchers have reported cloudiness or particle formation when using saline, which suggests peptide degradation or aggregation

Ideally, researchers should fully understand the advantages and limitations of mouse models to select the most appropriate one for addressing specific hypotheses

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