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Because GPX4 ablation or inaction is embryonically lethal, only heterozygous or conditional knockout mice can be analyzed (Table 1)

Role of dopamine neurons in reward and aversion: a synaptic plasticity perspective

Fredholm BB, Battig K, Holmn J, Nehlig A, Zvartau EE

This directly sensitizes osteoclasts to osteoclastogenic signals and entrains ROS-enhanced expression of cytokines that promote osteoclastic bone resorption