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Further, a recent study showed that cardiomyocytes produce diffusible redox mediators (e.g., H 2 O 2 ) that promote PCD in amastigotes and control intracellular proliferation of parasite (Estrada et al., 2018)

[Google Scholar] 10.World Health Organization

This behavior of the GS flux is caused by the competition between the higher inhibition of GS and GCL by GSH and the higher stimulation of GCL by estradiol [Figure 2]