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Chronic inflammation from misuse can trigger post-inflammatory hyperpigmentation on darker skin tones

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Voclosporin, a novel calcineurin inhibitor, was investigated in a phase II trial for lupus nephritis as a combination therapy with mycophenolate mofetil (AURA trial)

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It sits well under the ~500 Da Lipinski cutoff for good oral absorption, so absorption is built into the chemistry

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