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Primary human adult OLs undergo cell death in vitro following exposure to several T cell populations and natural killer cells, occurring in part through NKG2C/D receptor-ligand interactions 37,38

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That's well below toxic thresholds, but chronic administration over 6+ months hasn't been studied in controlled human trials

The functional consequences of oncogenic driver mutations therefore change via epigenetic mechanisms to promote metastasis

QA and QC procedures are critical aspects for the use of toxico-metabolomics from a regulatory perspective