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Although they are inhibited by GPX4 inhibitors such as RSL3 in vitro , treatment of cells with more specific TrxR inhibitors, e.g., TRi, does not induce ferroptosis [102] indicating that TrxR is not directly involved in ferroptosis

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The age distribution of the patients within these studies was 43-84 years and the included studies were published between 2003 and 2019

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