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A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria

The receptor is a glycoprotein that, like all G protein-coupled receptors, has a seven-transmembrane helix domain and an N-terminal extracellular signal peptide [7]

However, they work in different ways in the body

[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Nagao-Kitamoto H, Kitamoto S, Kuffa P, Kamada N

Disturbances in fluid balance (swelling), joint pain, muscle pain, stiffness of the hands and feet, numbness