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Of note, 16 patients in the intervention vs 7 in the control cohort achieved a 50% reduction of baseline consumption (p=0.01)

The use of the Nrf2 activator oltipraz effectively inhibits the expression of transferrin receptor (TFR) and divalent metal transporter (DMT1), which in turn suppresses ferroptosis and alleviates depressive symptoms (Zeng et al., 2023)

Other mechanisms Neurogenic inflammation in the lung involves airway obstruction, an increase in vascular permeability, extravasation of plasma and leukocytes, mucus hypersecretion and the release of additional inflammatory mediators 84

Therefore, LA can reduce liver fat accumulation caused by high-fructose diet and it is more effective when given before the development of fatty liver