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Conclusion Skin whitening treatments can be a viable option for those seeking a lighter complexion, but it's essential to approach them with caution and prioritize safety

MiR-199a-5p promotes ferroptosis-induced cardiomyocyte death responding to oxygenglucose deprivation/reperfusion injury via inhibiting Akt/eNOS signaling pathway

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As of mid-2025, no Phase II or Phase III human clinical trial for BPC-157 has been completed and published in a peer-reviewed journal

TABLE 1 Summary of RDP human clinical studies on Pycnogenol sorted by applications and by year of publication