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Severe generalized glutathione reductase deficiency after antitumour chemotherapy with BCNU[1,3-bis(chloroethyl)-1-nitrosourea]

1 Introduction Tumor-associated macrophages (TAMs), a dominant immune cell population in the tumor microenvironment (TME), significantly influence cancer progression ( Ferroptosis represents a metabolically driven form of regulated cell death that is fundamentally distinct from apoptosis, necroptosis, and pyroptosis ( Figure 1