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Microbial-derived short-chain fatty acids (SCFAs), generated through dietary fiber fermentation, drive the differentiation of regulatory T cells (Tregs), a process essential for immune tolerance and prevention of autoimmunity (Wang et al., 2024

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However, when used in doses greater than the RDA for dyslipidemia, or when used parenterally for the treatment of pellagra, niacin is categorized as pregnancy category C

Trends Cell Biol 30(10):805817

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