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Of those, 35 were preclinical and only one involved humans [8]

Aksoy S, Szumlanski CL, Weinshilboum RM

Second, B12 undergoes enterohepatic recirculation cobalamin secreted in bile is reabsorbed in the ileum through the same intrinsic-factor pathway so a genetic weakness in absorption is amplified over time by loss of the recycled pool