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ROS are also created as a result of phagocytosis by the RPE of the photoreceptors light absorbing photo-pigments contained in the outer segments (OS) 24

Losing weight reduces the inflammatory burden but the timeline is nonlinear, and the pathways that drive inflammation (particularly NF-B signalling) do not simply switch off as body fat declines

PMID: 39300112 Sci Signal Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

doi:10.1111/j.1742-4658.2011.08358.x

However, there was also a strong placebo effect, so the authors recommended reproducing the study with a larger group and longer duration