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Additionally, piperacillin-tazobactam is a substrate for OAT1 and OAT3, competitively decreasing tubular secretion of creatinine, and causing pseudo-toxicity due to rising serum creatinine levels without tubular damage

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The principle remains consistent: mechanism dictates timing, and bioavailability depends on administration discipline

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10.2147/NDT.S211288 36 DwyerA

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References Jzwiak M, Bauer M, Kamysz W, Kleczkowska P

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