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Regardless of whether the toxin actually precipitates an attack of porphyria, elimination on an on-going basis reduces the chance of an acute flare-up of the disease

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1 Introduction Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-limiting first step in the pentose phosphate pathway (PPP), converting nicotinamide adenine dinucleotide phosphate (NADP) to its reduced form: NADPH ( Figure 1A )