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Neuroscience (2014) 277:74754

In contrast, sustained or excessive ROS accumulation suppresses AMPK activity by destabilizing the AMPK-LKB1 complex, inducing inhibitory Ser485/491 phosphorylation via Akt/PKA signaling, and causing irreversible oxidative modifications of key cysteine residues (Yan et al., 2022)

Yang et al., 2018a

It is also not yet known whether such dysbiosis leads to ME/CFS, or whether it is a consequence of the metabolic and immunologic changes that occur in the disease (201)