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Additional mutations or copy number variants are rare at diagnosis and, depending on the tumour entity, may involve TP53 , CDKN2A and others

That being said, all studies were observational, meaning they cannot prove cause and effect

Subcutaneous dosing in research protocols is typically in the 1-2 mg range, though specific doses depend entirely on the study design and model

I am not convinced the data is fully there yet. Tatem said he expects the hearings to be a hard-fought battle, but hopes committee members will consider what he described as real-world data from tens of millions of doses administered between 2014 and 2023

Follow your program and local regulations.