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The mechanisms driving neurodegenerative disorders encompass oxidative stress, mitochondrial impairment, neuroinflammation, and protein misfolding, such as amyloid- plaques in AD and -synuclein in Parkinsons disease (Lamptey et al

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Macrophages play a vital role in modulating inflammation via arginine metabolism, with M1 macrophages utilising nitric oxide synthase 2 (NOS2) to metabolise arginine and produce inflammatory and anti-microbial nitric oxide (NO) as a metabolite