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10.1007/s00281-019-00742-7 39 SakaedaT.KadoyamaK.MinamiK.OkunoY

MOTS-c Strength: 50 mg Mitochondrial-derived peptide Expanded-strength option for patients seeking more advanced metabolic and recovery support strategies

OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship

2f, M-CuP degraded rapidly, retaining about 58% and 50% after 0.5 and 4 h, respectively