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B12 may lower homocysteine levels which could contribute to a lower odds of heart disease, but only in people who have a diagnosed B12 deficiency, Swenor says

Genetic variants in B12 metabolism pathways (e.g., MTHFR, MTR, MTRR genes) can influence how efficiently your body processes and utilizes B12, potentially affecting both side-effect risk and clinical benefit

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doi:10.1530/EJE-19-0566 Sposito AC, Berwanger O, de Carvalho LSF, Saraiva JFK