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Although these pathogens are less prevalent globally, their morbidity and mortality may be substantially underestimated due to limited surveillance, low prioritization in public health frameworks, and geographically restricted endemicity

1 With changing lifestyles, increasing environmental pollution, unavoidable occupational exposures, the continued prevalence of tobacco use, and an aging population, the morbidity, mortality and associated disease burden of pulmonary disease are increasing year by year

Observations of altered intestinal permeability have been reported in both patients diagnosed with RA and individuals with preclinical RA [72, 73]