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Heres a graphical overview of the synthesis pathways: Glutamate from glutamine: Glutamate can be synthesized from the amino acid glutamine with the help of the enzyme glutaminase (GLS and GLS2 genes)

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Pyruvate can then reach the mitochondria in aerobic circumstances, where pyruvate dehydrogenase complexes convert it into acetyl-CoA, thus integrating it into the tricarboxylic acid cycle (TCA)