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Furthermore, the expression of Bax in ovarian tissue was suppressed, while the expressions of SIRT1, PGC1, NRF1, COX IV, FSH receptors (FSHR), CYP19A1, PI3K, Bcl-2, and p-Akt/Akt were enhanced [39]

However, cancer cells enable proliferation, avoiding ROS-induced apoptosis, despite high mutagenesis

It is noteworthy, that some of the Kbhb are located in regions critical for the binding of enzymatic cofactors or co-enzymes, or in sites that alter the protein function when mutated (Huang et al., 2021)

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Another negative impact of zinc regarding NF-B activity appears through inhibition of lipopolysaccharide-induced activation of NF-B, which in the same time suppresses TNF- secretion in monocytes [39]