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In general, knock-out of the S100A8 or S100A9 leads to skin hyperplasia and aggravation of psoriatic symptoms in mouse models (121123)

The successive actions of GABAT and SSADH convert the carbon skeleton of GABA into the TCA cycle intermediate succinate

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146,147,148 These sex differences are concurrently influenced by sex hormones, with estrogens enhancing multiple immune parameters in a dose-dependent manner

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