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Drug - Methotrexate, MTX Methotrexate Toxicity- Treatment - - Sulfasalazine, SSZ - Hydroxychloroquine, HCQ - Steroids - Anti-TNF Biologic Agents - (Humira, Adalimumab) C C-Reactive Protein- CRP - ESR Rheumatoid Factor (RF)

Notably, aging-related AE1 protein conformational changes result in the appearance of a senescent-specific antigen recognized by autologous antibodies [75]